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Effect of endotoxin on the production of colony‐stimulating factor by human monocytes and macrophages
Author(s) -
Cline Martin J.,
Rothman Belina,
Golde David W.
Publication year - 1974
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040840205
Subject(s) - colony stimulating factor , macrophage colony stimulating factor , peripheral blood mononuclear cell , in vitro , monocyte , macrophage , immunology , bone marrow , peripheral blood , human bone , biology , chemistry , microbiology and biotechnology , haematopoiesis , biochemistry , stem cell
Colony‐stimulating factor (CSF) is necessary for the clonal growth of human bone marrow in vitro. Human blood monocytes and macrophages produce CSF. Endotoxin was found to increase the level of CSF generated by macrophages, but had no stimulatory effect on monocytes. Several other substances known to influence the pinocytic or phagocytic activity of mononuclear phagocytes failed to enhance cellular CSF generation.