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Studies on a chinese hamster line that is temperature sensitive for the commitment to DNA synthesis
Author(s) -
Smith B. J.,
Wigglesworth N. M.
Publication year - 1974
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040840114
Subject(s) - chinese hamster , dna synthesis , mitosis , hamster , permissive , cell culture , microbiology and biotechnology , dna , biology , line (geometry) , virology , genetics , geometry , mathematics
The Chinese hamster cell line K12 is temperature sensitive for the initiation of DNA synthesis and for the programming of rounding up to enter mitosis. Viability is lost expontentially after twelve hours at the non‐permissive temperature. This temperature sensitivity is reversed following exposure of K12 cells to SV40 virus.