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Evidence of a common site of action for the antitumor agents, hydroxyurea and guanazole
Author(s) -
Wright J. A.,
Lewis W. H.
Publication year - 1974
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040830314
Subject(s) - chinese hamster ovary cell , cell culture , pharmacology , site of action , cytotoxic t cell , biology , hamster , chemistry , in vitro , genetics , microbiology and biotechnology , endocrinology
Hydroxyurea and guanazole were used as selective agents in tissue culture to obtain independent Chinese hamster ovary cell lines resistant to the cytotoxic effects of hydroxyurea or guanazole. In all cases tested a cell line selected for resistance to one of the antitumor agents exhibited resistance to both drugs. This result supports the view that these two drugs act at a common site.