Premium
On the selection for the modal chromosome number in Chinese hamster cells
Author(s) -
Terzi M.
Publication year - 1972
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040800306
Subject(s) - biology , chinese hamster , ploidy , selection (genetic algorithm) , chromosome , chromosome number , karyotype , mitosis , modal , hamster , genetics , microbiology and biotechnology , evolutionary biology , cell culture , computer science , gene , chemistry , artificial intelligence , polymer chemistry
Chinese hamster cell lines have a strong tendency to maintain as modal chromosome number the euploid one characteristic of the species. By following the evolution of karyotypes in cloned subpopulation it has been possible to show that these pseudodiploid constitutions are not simply established due to a selective advantage but they are actually generated in populations where pseudodiploid classes had been absent. The possible role of the mitotic apparatus in keeping and restoring the euploid number is discussed.