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Regulation of mitochondrial respiration in senescence
Author(s) -
Chen Jenn C.,
Warshaw Joseph B.,
Sanadi D. Rao
Publication year - 1972
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040800115
Subject(s) - mitochondrion , respiration , glutamate receptor , biochemistry , inner mitochondrial membrane , malate dehydrogenase , biology , senescence , glutamate dehydrogenase , cytochrome c , palmitoylcarnitine , cytochrome , chemistry , microbiology and biotechnology , enzyme , botany , receptor
The ADP‐stimulated (State 3) respiration of myocardial mitochondria with glutamate‐malate, glutamate‐pyruvate, palmitylcarnitine and β‐hydroxybutyrate as substrates declined in rats after the age of 20 months. There was no significant decline in pyruvate‐malate, α‐oxoglutarate, palmityl‐CoA, succinate and ascorbate cytochrome c oxidation. Skeletal muscle mitochondria from senescent animals showed a similar decline in glutamate‐malate oxidation but not in palmityl‐CoA, palmitylcarnitine, succinate and ascorbate‐cytochrome c oxidation. The controlled oxidation with ADP‐limiting (State 4) and the ADP/O ratio were not affected. The results indicate an alteration in the subtle regulatory capacity for mitochondrial oxidation in senescent rats. It is suggested that the alteration may be in certain anion transport and associated functions across the mitochondrial membrane or dehydrogenase activity.