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Lymphopoiesis in the rat. I. The effect of pool size on lymphocyte production
Author(s) -
Vaughan W. P.,
McGregor D. D.
Publication year - 1972
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040800102
Subject(s) - lymphopoiesis , lymphocyte , biology , immunology , production (economics) , microbiology and biotechnology , haematopoiesis , economics , stem cell , macroeconomics
A method is described for measuring lymphopoiesis that enables the production of recirculating and non‐recirculating small lymphocytes to be estimated simultaneously. Using this technique, experiments were undertaken to determine whether the production of recirculating cells is influenced by the number present in the recirculating lymphocyte pool. The results suggest that neither a massive lymphocyte transfusion nor depletion of the pool by whole body irradiation or chronic lymph drainage affect the rate at which recirculating small lymphocytes are generated.