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Inhibition of cellular adhesiveness by sulfhydryl blocking agents
Author(s) -
Grinnell Frederick,
Srere Paul A.
Publication year - 1971
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040780119
Subject(s) - dithiothreitol , adhesion , blocking (statistics) , chemistry , adhesive , polystyrene , reagent , biophysics , cell adhesion , biochemistry , microbiology and biotechnology , biology , enzyme , organic chemistry , polymer , statistics , mathematics , layer (electronics)
Rat hepatoma cells rapidly adhered to the polystyrene surfaces of culture bottles. The adhesiveness of the cells was inhibited by sulfhydryl blocking reagents including mercurials, arsenicals, and alkylating agents. Inhibition was prevented, and in some cases reversed, by the addition of dithiothreitol to the adhesive medium. The current model explaining cellular adhesion is discussed in the light of these observations.