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Transformation of granulocytes to macrophages in bone marrow colonies in vitro
Author(s) -
Metcalf Donald
Publication year - 1971
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040770216
Subject(s) - in vitro , bone marrow , macrophage , granulocyte , transformation (genetics) , agar , chemistry , immunology , biology , pathology , medicine , biochemistry , bacteria , genetics , gene
Single cells from developing two day granulocytic bone marrow colonies were transfered in agar cultures. After three to five days, 48 of 239 transfered single cells had transformed to single macrophages or proliferated to form aggregates of pure macrophages or mixed macrophage‐granulocyte aggregates. Some granulocytes in colonies developing in vitro from bone marrow cells appear to have the capacity to transform to macrophages.