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From cell biology to immunology—A short trip
Author(s) -
Herzenberg Leonard A.
Publication year - 1970
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040760309
Subject(s) - allotype , immunology , antigen , biology , immune system , antibody , b cell , in utero , t cell , fetus , genetics , pregnancy
Immunologic memory and immunoglobulin allotype suppression are discussed as problems in Cell Biology. Memory, the ability of an animal after a first antigenic exposure to give a heightened and faster immune response upon a second exposure to the same antigen, is shown to be a property of bone marrow‐derived cell lines. Expression of this memory depends on interaction with thymus‐derived cells from either non‐immunized or immunized mice. Chronic allotype suppression is described for the first time. It is initiated by in utero or neonatal exposure of (SJL × BALB/c)F 1 mice, allotype a/b, to anti b antibody. Suppression lasts for long periods and continues in irradiated recipients which have received lymphoid cells from suppressed donors. Selection against b allotype producing cell precursors can explain suppression.