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Further studies on the differentiation of a cell line of myeloid leukemia
Author(s) -
Ichikawa Yasuo
Publication year - 1970
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040760207
Subject(s) - thermolabile , myeloid leukemia , cell culture , leukemia , myeloid , microbiology and biotechnology , cellular differentiation , biology , chemistry , cancer research , immunology , biochemistry , gene , genetics , enzyme
A limited time of contact with a conditioned medium from embryo cells induced phagocytotic activity in a cell line of myeloid leukemia followed by the loss of colony forming and leukemogenic capacity. After two days in a high concentration of the conditioned medium, the colonies showed morphological changes which indicated the differentiation of this line of cells. The differentiation‐stimulating factor present in the conditioned medium was relatively thermolabile, while the growth‐stimulating factor was highly thermostable. Both factors could pass through a dialysis membrane.