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Strain‐specific mitotic inhibition in large mononucleate amoebae
Author(s) -
Jeon K. W.,
Lorch I. J.
Publication year - 1970
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040750208
Subject(s) - biology , mitosis , strain (injury) , antimitotic agent , heterologous , microbiology and biotechnology , biochemistry , anatomy , microtubule , gene , tubulin
A strain‐specific antimitotic substance is present in large mononucleate amoebae. It inhibits mitosis when injected into amoebae of heterologous strains. The antimitotic substance has been isolated from homogenized cells, and some of its properties have been studied. The results obtained show that the active factor is a protein(s) of molecular weight between 200,000 and one million. The activity of this substance differs from other known antimitotic agents in that its action is strain‐specific.