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A melanin‐dispersing effect of cyclic adenosine monophosphate on Fundulus melanophores
Author(s) -
Novales R. R.,
Fujii R.
Publication year - 1970
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040750116
Subject(s) - chromatophore , adenosine , fundulus , adenosine monophosphate , melanophore , melanin , chemistry , cyclic adenosine monophosphate , medicine , endocrinology , biology , biochemistry , genetics , receptor , fishery , fish <actinopterygii>
Treatment of Fundulus melanophores with adenosine 3′,5′‐monophosphate (cyclic AMP) is followed by reversible melanin dispersion in these cells. Adenosine 3′‐monophosphate and adenosine 5′‐monophosphate both have a similar, but weaker dispersing action. In addition, adenosine 5′‐monophosphate also has a melanin aggregating effect. These results are interpreted to mean that nerve transmitters may act by controlling the level of cyclic AMP within the Fundulus melanophore.