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Replication of the RNA genome
Author(s) -
August J. T.,
Eoyang Lillian,
De Fernandez M. T. Franze,
Hasegawa S.,
Kuo C. H.,
Rensing U.,
Shapiro Lucille
Publication year - 1969
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040740419
Subject(s) - rna , rna dependent rna polymerase , biology , rna polymerase , genome , polymerase , bacteriophage , dna , genetics , microbiology and biotechnology , gene , escherichia coli
Several steps in the synthesis in vitro of infectious bacteriophage RNA can now be described. The reaction catalyzed by the Qβ RNA polymerase is known to involve several components, including the enzyme, host cell factors, Qβ RNA template, and the strand complementary to the Qβ RNA. The interaction of these components and the mechanims of the reaction appears to be considerably more complex than was proposed in earlier models.