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Discrepancies between precursor uptake and DNA synthesis in mammalian cells
Author(s) -
Smets L. A.
Publication year - 1969
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040740109
Subject(s) - thymidine , dna synthesis , dna , deoxycytidine , chemistry , biochemistry , stimulation , tritium , biology , microbiology and biotechnology , genetics , cancer , neuroscience , physics , gemcitabine , nuclear physics
The incorporation of tritiated thymidine and deoxycytidine into DNA of x‐irradiated mammalian cells was studied. Both inhibition and stimulation were found due to pool changes rather than to effects on DNA synthesis, indicating that precursor uptake can be a misleading method to measure DNA synthesis rate.