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Development of the mouse hematopoietic system. II. Estimation of spleen and liver “stem” cell number
Author(s) -
Barker Jane E.,
Keenan Mary Ann,
Raphals Lisa
Publication year - 1969
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040740107
Subject(s) - haematopoiesis , spleen , biology , stem cell , gestation , andrology , fetus , hematopoietic stem cell , immunology , population , bone marrow , microbiology and biotechnology , pregnancy , medicine , genetics , environmental health
Colony‐forming cells (CFU), which have the general properties of hemopoietic “stem” cells, appear to be augmented in the mouse fetal liver from 12–18 days gestation and then decrease in the newborn. This finding suggests that few, if any, hemopoietic “stem” cells remain in the adult liver, an organ which appears to be unable to function erythropoietically, even at times of severe crises. In the spleen, and active adult as well as embryonic hematopoietic organ, the total number of CFU increases from 18 days gestation until at least 7 days after birth. Spleen and liver CFU augmentation seems to occur in cojunction with an analogous expansion of non‐hematopoietic cells. The data suggests, in fact, that while there is an increase in the total number of liver CFU, there is also a dilution of liver CFU in the total cell population at successively later gestational ages.