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The single cell origin of normal granulocyte colonies in vitro
Author(s) -
Paran Michael,
Sachs Leo
Publication year - 1969
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040730113
Subject(s) - granulocyte , in vitro , cloning (programming) , haematopoiesis , biology , microbiology and biotechnology , bone marrow , macrophage , cell , immunology , chemistry , biochemistry , stem cell , computer science , programming language
It has been shown by re‐cloning of colonies formed in vitro from rat bone marrow cells, that normal granulocyte colonies can originate from single cells. No mixed macrophage (M) and granulocyte (G) colonies were obtained after re‐cloning either M or G colonies. The results indicate, that clones of normal granulocytes and macrophages can be obtained in vitro , and that the mixed primary M and G colonies formed after seeding hematopoietic cells from animals presumably originate from a mixture of M and G cells.