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Impairment of deoxyribonucleic acid synthesis by dietary zinc deficiency in the rat
Author(s) -
Sandstead Harold H.,
Rinaldi Robert A.
Publication year - 1969
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040730111
Subject(s) - zinc deficiency (plant disorder) , zinc , dna synthesis , in vivo , dna , thymidine , parenchyma , biochemistry , in vitro , biology , nuclear dna , chemistry , medicine , endocrinology , genetics , gene , botany , mitochondrial dna , organic chemistry
Dietary zinc deficiency has been shown to decrease the in vivo incorporation of thymidine into the nuclear DNA of liver parenchymal cells in the rat. A single injection of 100 μg of zinc was sufficient to rapidly reverse the effect of zinc deficiency on the synthesis of DNA.