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The stimulation of tumor cell growth by a substance produced by normal and tumor cells
Author(s) -
Ichikawa Yasuo,
Paran Michael,
Sachs Leo
Publication year - 1969
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040730107
Subject(s) - stimulation , tumor cells , myeloid cells , biology , myeloid , cell growth , cancer research , cell , endocrinology , microbiology and biotechnology , medicine , immunology , biochemistry
It has been shown that a dialyzable substance produced by normal and tumor cells can stimulate the growth of a myeloid, erythroid, and two lymphoid leukemias, and a sarcoma. The growth stimulation of the tumor cells was observed as an increase in cloning efficiency and number of cells per colony. Rat granulocytes stimulated the growth of mouse tumor cells as efficiently as a variety of mouse cells. The stimulating substance was found in conditioned medium, and it was produced by all the normal and tumor cells tested.