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The need for direct cell contact in “contact” inhibition of cell division in culture
Author(s) -
Schutz Leonard,
Mora Peter T.
Publication year - 1968
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040710102
Subject(s) - cell division , contact inhibition , cell , microbiology and biotechnology , cell growth , division (mathematics) , biophysics , cell culture , contact angle , biology , chemistry , materials science , biochemistry , genetics , mathematics , composite material , arithmetic
Non‐dividing mouse embryo fibroblasts which grew to a confluent cell density on one side of an ultra‐thin filter did not inhibit the active multiplication of the same type of cells growing at low cell density on the other side of the filter directly opposite the confluent side. The close proximity of the cells across the filter was not sufficient to cause inhibition of cell division. The phenomenon of “contact” or “density dependent” inhibition of cell division is therefore probably not mediated by a cellular product which remains concentrated near the cell surface. The degree of contact inhibition of cell division was correlated with the local cell density on the same side of the filter. This relationship was found to be influenced strongly by the surface on which the cells were growing.