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Colony stimulating activity of serum from germfree normal and leukemic mice
Author(s) -
Metcalf Donald,
Foster Roger,
Pollard Morris
Publication year - 1967
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040700118
Subject(s) - bone marrow , colony stimulating factor , in vitro , peripheral blood mononuclear cell , biology , immune system , immunology , leukemia , microbiology and biotechnology , haematopoiesis , biochemistry , stem cell
Serum from germfree Swiss/HaM mice exhibited a reduced capacity to stimulate granulocytic and mononuclear cell colony formation by DBA/1 bone marrow cells in vitro when compared with serum from conventional Swiss/HaM mice. Sera from germfree preleukemic and leukemic AKR mice exhibited strong colony stimulating activity, indicating that the increased colony stimulating activity previously observed in the serum of conventional leukemic mice is not the consequence of bacterial or fungal infections supervening in leukemic animals with deficient immune responses.