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Experimental coxsackie B‐3 virus infection in Citellus lateralis
Author(s) -
Dempster G.,
Grodums E. I.,
Spencer W. A.
Publication year - 1966
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.1040670309
Subject(s) - hibernation (computing) , virus , biology , virology , titer , inoculation , antibody , immunology , state (computer science) , algorithm , computer science
Coxsackie B‐3 virus produces a mild infection which passes unnoticed in the non‐hibernating Citellus lateralis . A severe infection occurs in the hibernating animal. The progress of infection in the hiberating animal is related to the number of arousal hours and quite independent of the number of infected days. Nevertheless, it has been shown that the low‐temperature hibernation phase has a potentiating effect upon subsequent viral production. Infective virus has not been found in the inoculated brown fat pads during the hibernation phase but very high virus titers are recorded 48 hours after arousal. This results in an earlier viraemia and earlier and higher titers in other organs of the body. A similar effect is noted when virus is inoculated at the very beginning of the arousal phase. While most animals recover with subsequent antibody development, a few succumb. Antibody development is slow and related only to the number of arousal hours experienced. Particular note is made of the fact that an animal may successfully resume hibernation despite complete loss of the axillary brown fat pads.