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Gonadotropin and steroid hormones stimulate proliferation of the rat ovarian surface epithelium
Author(s) -
Stewart Sherri L.,
Querec Troy D.,
Gruver Bria.,
O'Hare Brendan,
Babb James S.,
Patriotis Christos
Publication year - 2004
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.10401
Subject(s) - ovulation , ovary , human chorionic gonadotropin , hormone , gonadotropin , endocrinology , medicine , biology , infertility , ovarian cancer , ovulation induction , andrology , cancer , pregnancy , genetics
The ovarian surface epithelium (OSE) is a single layer of flattened or cuboidal cells covering the ovary. Ninety percent of all human ovarian malignancies arise from this layer of cells. Incessant ovulation, hyperovulation induced by infertility treatment, and hormone replacement therapy have been suggested as risk factors for ovarian cancer. In this study, two groups of rats, with and without surgically induced injury to the ovary, were treated with 17β‐estradiol, pregnant mare's serum gonadotropin (PMSG), human chorionic gonadotropin (hCG), or the combination PMSG/hCG, and the proliferative response of the OSE cells was measured using bromodeoxyuridne (BrdU) and 3 H‐thymidine. All hormones, alone or in combination with ovarian surgery, were found to increase significantly the rate of proliferation of the rat OSE. These data demonstrate that hormones associated with infertility treatments and hormone replacement therapy, as well as injury‐ or ovulation‐induced rupture of the ovarian surface, stimulate the rat OSE, and hence could have a role in the development of ovarian cancer via proliferation‐associated mutagenesis, or alternatively, by promoting the rapid selection of OSE cells with accumulated mutations. J. Cell. Physiol. 198: 119–124, 2004. © 2003 Wiley‐Liss, Inc.