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cDNA array technology in melanoma: An overview
Author(s) -
Baldi Alfonso,
Santini Daniele,
uca Antonio De L,
Paggi Marco G.
Publication year - 2003
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.10255
Subject(s) - complementary dna , melanoma , computational biology , gene , biology , cancer , gene expression , genetics , bioinformatics , cancer research
Genetic aberrations, mostly resulting in changes in gene expression, are critical events in cancer onset and progression. The advent of the cDNA array technology allows the screening and the efficient measurement of expression of thousands genes simultaneously in a wide spectrum of experimental and clinical models. This genomic scale approach is being currently used to obtain global views of human cancer gene expression and to identify genetic markers that might be important for diagnosis, prognosis, and therapy. This review discusses some recent findings obtained by means of cDNA arrays investigating the human melanoma. J. Cell. Physiol. 196: 219–223, 2003. © 2003 Wiley‐Liss, Inc.