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Role of the IGF‐I receptor in the regulation of cell–cell adhesion: Implications in cancer development and progression
Author(s) -
Mauro Loredana,
Salerno Michele,
Morelli Catia,
Boterberg Tom,
Bracke Marc E.,
Surmacz Eva
Publication year - 2003
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.10207
Subject(s) - microbiology and biotechnology , cell adhesion , receptor tyrosine kinase , cell growth , cancer cell , biology , carcinogenesis , tyrosine kinase , cancer research , cell , signal transduction , adhesion , cancer , chemistry , biochemistry , genetics , organic chemistry
The insulin‐like growth factor‐I receptor (IGF‐IR) is a ubiquitous multifunctional tyrosine kinase that has an important role in normal cell growth and development. However, abnormal stimulation of IGF‐IR signaling has been implicated in the development of different types of tumors. The strong antiapoptotic activity of IGF‐IR has been recognized as critical in IGF‐I‐dependent tumorigenesis, however, the impact of other IGF‐IR functions, such as regulation of cell–cell and cell–matrix adhesion are also increasingly acknowledged. Here, on the model of breast cancer cells, we discuss how IGF‐IR‐dependent regulation of intercellular adhesion may affect cell survival, resistance to antiestrogens, and invasion. © 2002 Wiley‐Liss, Inc.