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Atrial natriuretic factor inhibits mitogen‐induced growth in aortic smooth muscle cells
Author(s) -
Baldini P.M.,
De Vito P.,
Fraziano M.,
Mattioli P.,
Luly P.,
Di Nardo P.
Publication year - 2002
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.10155
Subject(s) - growth factor , cell growth , medicine , endocrinology , smooth muscle , vascular smooth muscle , platelet derived growth factor receptor , mechanism (biology) , biology , receptor , microbiology and biotechnology , chemistry , biochemistry , philosophy , epistemology
Atrial natriuretic factor (ANF) is a polypeptide able to affect cardiovascular homeostasis exhibiting diuretic, natriuretic, and vasorelaxant activities. ANF shows antimitogenic effects in different cell types acting through R 2 receptor. Excessive proliferation of smooth muscle cells is a common phenomenon in diseases such as atherosclerosis, but the role of growth factors in the mechanism which modulate this process has yet to be clarified. The potential antimitogenic role of ANF on the cell growth induced by growth factors appears very intriguing. Aim of the present study was to investigate the possible involvement of ANF on rat aortic smooth muscle (RASM) cells proliferation induced by known mitogens and the mechanism involved. Our data show that ANF, at physiological concentration range, inhibits RASM cell proliferation induced by known mitogens such as PDGF and insulin, and the effect seems to be elicited through the modulation of phosphatidic acid (PA) production and MAP kinases involvement. J. Cell. Physiol. 193: 103–109, 2002. © 2002 Wiley‐Liss, Inc.