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Reasons for nonadherence and response to treatment in an adherence intervention trial for relapsing–remitting multiple sclerosis patients
Author(s) -
Schoor Rachel,
Bruce Amanda,
Bruce Jared,
Goggin Kathy,
Schanfarber Bethany,
BradleyEwing Andrea,
Thelen Joanie,
Glusman Morgan,
Lynch Sharon G.,
Strober Lauren,
Catley Delwyn
Publication year - 2019
Publication title -
journal of clinical psychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.124
H-Index - 119
eISSN - 1097-4679
pISSN - 0021-9762
DOI - 10.1002/jclp.22725
Subject(s) - multiple sclerosis , observational study , psychology , intervention (counseling) , relapsing remitting , clinical psychology , coding (social sciences) , randomized controlled trial , medicine , psychiatry , statistics , mathematics
Objectives To explore whether patients in an adherence trial who appeared not to take disease modifying therapy (DMT) for avoidance reasons could be reliably identified, by observational coding, for their main reason of not taking DMT. To determine whether reason groups could be distinguished by clinical and self‐report psychological characteristics and intervention outcomes. Method Participants were multiple sclerosis patients ( N = 78, 88.5% female, mean age 45.64) demotivated to take DMT. Audio recordings of the sessions were coded for the main reason of not taking DMT. Reason groups were compared based on patient characteristics and intervention outcomes. Results Avoidance and three other reasons for not taking DMT (side effects, cost, and mild course) were reliably identified (κ = 0.88). Patient characteristics failed to distinguish participants in the Avoidance group, which also had poorer outcomes ( X 2 [2, n = 73] = 6.35, p = 0.036). Conclusions Patients not taking DMT for avoidance reasons may need novel methods to identify them and encourage (re‐)initiation.