Open AccessEffects of co‐infection with Clonorchis sinensis on the sex hormones levels in male patients with chronic hepatitis B
Author(s) -
Dong Huimin,
Shang Mei,
Luo Minqi,
Chen Wenya,
Hu Bo
Publication year - 2022
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.24663
Subject(s) - clonorchis sinensis , testosterone (patch) , hormone , medicine , cirrhosis , sex hormone binding globulin , prolactin , luteinizing hormone , hepatitis b , follicle stimulating hormone , endocrinology , gastroenterology , immunology , androgen , helminths
Objective We evaluated the levels of sex hormones in male hepatitis B patients co‐infected with Clonorchis sinensis ( C. sinensis ). Methods A total of 136 male individuals were enrolled in this study, including 27 healthy controls, 28 patients with C. sinensis mono‐infection, 19 patients with only chronic hepatitis B, 18 patients with post‐hepatitis B liver cirrhosis, 26 chronic hepatitis B patients co‐infected with C. sinensis , and 18 post‐hepatitis B liver cirrhosis patients coinfected with C. sinensis . Serum levels of progesterone (P), luteinizing hormone (LH), estradiol (E2), testosterone (T), prolactin (PRL), and follicle stimulating hormone (FSH) in these groups were measured. Results The results showed that compared with the LC group, the LC + C. sinensis co‐infected group had an increase in E2 but decrease in T and FSH. The levels of E2 in CHB + C. sinensis co‐infected patients were significantly higher than those in CHB mono‐infected patients, but the significantly lower levels of T were observed. Compared with HCs group, the LC group showed significant increase in all terms of sex hormones, except PRL. By contrast, the CHB mono‐infected group presented an apparent decrease in E2, T, and PRL than the HCs group. However, there were no significant differences in sex hormone levels between the C. sinensis mono‐infected patients and HCs. Conclusion This study suggests that C. sinensis co‐infection aggravates the sex hormone disturbance in HBV patients at both chronic hepatitis and cirrhosis stages, providing evidences for potential strategies in disease prevention and treatment.