Open AccessSerum uric acid to creatinine ratio is associated with higher prevalence of NAFLD detected by FibroScan in the United States
Author(s) -
Wang Rusha,
Xue Feiben,
Wang Liping,
Shi Guangxia,
Qian Guoqing,
Yang Naibin,
Chen Xueqin
Publication year - 2022
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.24590
Subject(s) - medicine , odds ratio , creatinine , fatty liver , gastroenterology , confounding , uric acid , national health and nutrition examination survey , steatosis , nonalcoholic fatty liver disease , logistic regression , subgroup analysis , confidence interval , endocrinology , disease , population , environmental health
Background The association between the serum uric acid (sUA) to creatinine ratio (sUA/Cr) and non‐alcoholic fatty liver disease (NAFLD) has not been sufficiently clarified. In this study, we investigated the relationship between sUA/Cr and NAFLD among participants in the United States. Methods We performed a cross‐sectional study based on data from the National Health and Nutrition examination Survey (NHANES) 2017–2018. A measured controlled attenuation parameter (CAP) value of ≥274 dB/m detected by Fibroscan was used to identify hepatic steatosis. SUA/Cr was calculated as sUA divided by serum creatinine. Multivariate logistic regression analysis was used to estimate the association between sUA/Cr and NAFLD. The adjusted odds ratio (OR) of sUA/Cr for NAFLD was estimated, and subgroup analysis stratified by sex was also conducted. The nonlinear relationship between sUA/Cr and NAFLD was further described using smooth curve fittings and threshold‐effect analysis. Results We found that sUA/Cr was positively correlated with NAFLD status after fully adjustment for confounding factors. In subgroup analysis stratified by sex, the positive interaction between sUA/Cr and NAFLD status only existed in women but not in men. Moreover, the nonlinear association between sUA/Cr and NAFLD status was an inverted U‐shaped curve with an inflection point at 9.7 among men. Conclusions Our study identified that sUA/Cr was positively associated with the risk of NAFLD among individuals in the United States. Moreover, the correlation between sUA/Cr and NAFLD differed according to sex.