Open AccessEffect of artificial skin membrane on the expression of miR‐155 and miR‐506‐3p in patients with second‐degree burns
Author(s) -
Li Fei,
Wan Dong Wu,
Hu Jun,
Qin Runhe
Publication year - 2022
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.24564
Subject(s) - medicine , fibrosis , wound healing , inflammation , rehabilitation , pathology , surgery , physical therapy
Abstract Objective To investigate the effect of artificial skin on the expression of miR‐155 and miR‐506‐3p in patients with second‐degree burns. Methods The study subjects included 50 patients with second‐degree burns treated from July 2019 to July 2021. The control group received routine nursing, while the research group received both routine and artificial skin intervention simultaneously. The changes in wound tissue fibrosis and prognosis were observed. The expression levels of miR‐155 and miR‐506‐3p and their downstream regulatory factors were detected and correlated with the rehabilitation of patients after artificial skin treatment. Results After treating second‐degree burns with artificial skin membranes, the patient's wound tissue fibrosis and inflammation level improved. At the same time, the expression levels of miR‐155 and miR‐506‐3p in related tests were higher than those in patients with available treatment. Conclusion The effect of artificial skin membrane on the wound healing of second‐degree burn patients may be realized by influencing the expression levels of miR‐155 and miR‐506‐3p and their related signaling pathways.