Open AccessMALT1 in asthma children: A potential biomarker for monitoring exacerbation risk and Th1/Th2 imbalance‐mediated inflammation
Author(s) -
Liu Liying,
Gao Yang,
Si Yonghua,
Liu Baohuan,
Liu Xingyue,
Li Guanhui,
Wang Rong
Publication year - 2022
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.24379
Subject(s) - exacerbation , medicine , asthma , immunology , biomarker , tumor necrosis factor alpha , inflammation , immune system , biology , biochemistry
Background Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) participates in the immune‐related allergic response and inflammation flare, while its clinical role in asthma children is still unknown. Herein, this study aimed to investigate MALT1 expression, and its correlation with exacerbation risk, T helper (Th)1, Th2 cells (and their secreted cytokines), as well as inflammatory cytokines in asthma children. Methods Sixty children with asthma exacerbation and 60 children with remission asthma were enrolled in this study; then their blood MALT1, Th1, Th2 cells, tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), interferon‐gamma (IFN‐γ), and interleukin‐4 (IL‐4) were detected. Besides, blood MALT1 in another 20 health controls was also determined. Results Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 was highest in children with asthma exacerbation, followed by children with remission asthma, and lowest in health controls ( p < 0.001). MALT1 could distinguish children with asthma exacerbation from children with remission asthma (area under the curve (AUC): 0.757, 95% CI: 0.670–0.843). In children with asthma exacerbation, MALT1 was negatively linked with IFN‐γ ( p = 0.002) and Th1 cells ( p = 0.050), but positively related to Th2 cells ( p = 0.027) and exhibited a positive correlation trend (without statistical significance) with IL‐4 ( p = 0.066); meanwhile, MALT1 was positively correlated with exacerbation severity ( p = 0.010) and TNF‐α ( p = 0.003), but not linked with IL‐6 ( p = 0.096). In children with remission asthma, MALT1 only was negatively associated with Th1 cells ( p = 0.023), but positively linked with TNF‐α ( p = 0.023). Conclusion Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 serves as a potential biomarker for monitoring exacerbation risk and Th1/Th2 imbalance‐mediated inflammation of asthma children.