Open AccessLow levels of serum IL‐39 are associated with autoimmune thyroid disease
Author(s) -
Weng Linjie,
Huang Guoqing,
Gong Luping,
Xu Jialu,
Mao Yushan,
Li Yan,
Li Mingcai
Publication year - 2022
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.24284
Subject(s) - medicine , thyroiditis , white blood cell , endocrinology , triiodothyronine , thyroid , immunology , gastroenterology
Background Interleukin (IL)‐39 is a novel member of IL‐12 cytokine family, but its role in autoimmune thyroid diseases (AITD) is unclear. The aim of the present study was to determine serum levels of IL‐39 in Hashimoto's thyroiditis (HT) and Graves' disease (GD) patients. Methods A total of 48 patients with HT, 50 patients with GD, and 45 healthy controls (HCs) were recruited for this study. Levels of serum IL‐39 were determined by ELISA. Results Compared with HC group, levels of serum IL‐39 in patients with HT ( p < 0.05) and GD ( p < 0.01) were drastically reduced. Among patients with HT, serum IL‐39 levels had a positive correlation with white blood cell count (WBC) count and free triiodothyronine level. Among patients with GD, the levels of IL‐39 in serum were positively correlated with WBC count and C‐reactive protein levels. Conclusions IL‐39 may be a new potential predictor for patients with HT and GD.