Open AccessPredictive value of NLR and PLR in missed miscarriage
Author(s) -
Liu Dan,
Huang Xinyan,
Xu Zhengxian,
Chen Minzhi,
Wu Manyu
Publication year - 2022
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.24250
Subject(s) - mean platelet volume , medicine , red blood cell distribution width , miscarriage , receiver operating characteristic , white blood cell , complete blood count , platelet , retrospective cohort study , lymphocyte , gastroenterology , obstetrics , neutrophil to lymphocyte ratio , pregnancy , gynecology , biology , genetics
Abstract Background The aim of the study was to investigate the predictive value of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in missed miscarriage. Methods In this retrospective cohort study, a total of 400 women (involving 200 with missed early miscarriage and 200 with normal pregnancy but terminate by artificial abortion) were included. General clinical data and complete blood count (CBC) such as white blood cells (WBC), red blood cells (RBC), platelet (PLT), red blood cell distribution width‐standard deviation (RDW‐SD), platelet distribution width (PDW), mean platelet volume (MPV), neutrophil count, and lymphocyte count were collected, and the NLR and PLR were calculated for both groups. Receiver operating characteristic curve (ROC) was used to calculate the predictive value. Results There was no significant difference in the WBC, RBC, PLT, RDW‐SD, PDW, neutrophil, lymphocyte, NLR, and PLR between the two groups ( p > 0.05).But MPV was lower in the missed early miscarriage group than in the control group ( p < 0.05), and the area under the working curve (AUC) of ROC was 0.58, specificity and sensitivity was 69% and 47%, respectively. Conclusion NLR and PLR were not the suitable indictor for missed miscarriage, but MPV should be a concern in the first trimester.