Open AccessAssociation of a common genetic variant (insertion/deletion) in ACE gene with prostate cancer susceptibility in a Tunisian population
Author(s) -
Said Rahma,
Jenni Rim,
Boussetta Sami,
Ammous Feryel,
Zouari Skander,
Zaghbib Selim,
Chakroun Marouene,
Derouiche Amine,
Chebil Mohamed,
Ouerhani Slah
Publication year - 2022
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.24129
Subject(s) - genotype , prostate cancer , allele , angiotensin converting enzyme , medicine , genetic predisposition , oncology , genetics , polymerase chain reaction , metastasis , biology , gastroenterology , cancer , gene , blood pressure
Background Angiotensin‐converting enzyme ( ACE ) plays a pivotal role in several pathologies including cancers. The association of insertion/deletion (I/D) polymorphism of the ACE gene with prostate cancer (PC) risk remains controversial. We aimed to investigate for the first time, to our Knowledge, in North Africa the potential relationship between ACE I/D polymorphism with PC susceptibility and clinical outcomes of PC patients. Methods This case‐control study included 143 healthy individuals and 124 patients diagnosed with PC. Using genomic DNA, the samples were genotyped for ACE I/D polymorphism by polymerase chain reaction (PCR). Results We found that The D allele is significantly associated with an increased risk of PC and D/D + D/I genotypes were at 3 times increased risk of PC ([ p = 0.005], OR = 2.95, IC 95% = 1.26–7.09) compared with I/I genotype ( p = 0.003, OR = 0.3, IC 95% = 0.12–0.74). We observed an association between D/D and D/I genotypes with advanced age (≥70 years) ( p = 0.014; r 2 = 0.22). Furthermore, there is a significant prediction of advanced Gleason score ≥8 based on epidemiological parameters and ACE genotype ( p = 0.000; R 2 = 0.349), although no significant association was observed with stage and metastasis. Conclusion The ACE I/D polymorphism is likely to predispose to PC and could play a role in PC progression and aggressiveness.