Open AccessAssociation of serum adiponectin and leptin levels with renal function in kidney transplant recipients with or without new‐onset diabetes after transplantation
Author(s) -
Pham Vu Thuy,
Can Van Mao,
Dang Thanh Chung,
Nguyen Minh Tuan,
Nguyen Trung Kien,
Nguyen Duy Toan,
Do Quyet,
Tran Viet Tien,
Le Viet Thang
Publication year - 2021
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.24000
Subject(s) - adiponectin , medicine , leptin , diabetes mellitus , endocrinology , transplantation , renal function , adipokine , kidney transplantation , gastroenterology , obesity , insulin resistance
Purpose To evaluate serum adiponectin and leptin concentration in new‐onset diabetes after transplantation (NODAT) and non‐NODAT patients and association with renal function in kidney transplant recipients (KTRs). Patients and methods A study of 314 consecutive adults KTRs divided into four groups: 236 individuals without NODAT who had renal insufficiency (RI; n = 56) or normal renal function ( n = 180) and 78 patients with NODAT who had RI ( n = 17) or normal renal function ( n = 61). NODAT was diagnosed based on venous fasting blood glucose or HbA1c with the criteria of the American Diabetes Association. Renal insufficiency was defined according to KDOQI 2002 guidelines. Results In the NODAT group, the median level of serum adiponectin was lower than that of non‐NODAT one (30 µg/ml vs 37.15 µg/ml, p < 0.001); in contrast, the median leptin concentration was higher (4.27 ng/ml vs 4.05 ng/ml, p = 0.024). In the RI group, both median serum adiponectin and leptin levels were higher than those of non‐RI one (Adiponectin: 40.01 µg/ml vs 33.7 µg/ml; Leptin: 4.51 ng/ml vs 3.91 ng/ml, p < 0.001 both). We found that BMI was related to both adiponectin and leptin levels in both NODAT, non‐NODAT, and all subject groups, based on univariate and multivariate linear regression analysis. Conclusion New‐onset diabetes after transplantation, BMI, and renal insufficiency were affected to the serum level of adiponectin and leptin in KTRs.