Open AccessLevels of nasal exhaled hydrogen sulfide in the general population and allergic rhinitis patients
Author(s) -
Li Lisha,
Liu Yonglin,
Wang Qiang,
Wang Zixi,
Cui Le,
Xu Yingyang,
Guan Kai
Publication year - 2021
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23678
Subject(s) - medicine , population , gastroenterology , biomarker , chemistry , environmental health , biochemistry
Background Objective measures used for the differential diagnosis and severity assessment of allergic rhinitis (AR) are still lacking. The involvement of hydrogen sulfide (H 2 S) in the development of AR indicates that nasal exhaled H 2 S (NeH 2 S) has potential as a biomarker to be used in AR patients. This study aimed to evaluate the application value of NeH 2 S measurement in the diagnosis and assessment of AR. Methods This study was a multi‐center cross‐sectional survey conducted in Northwestern China. Demographic information collection and rhinitis assessment were completed through questionnaires. The level of NeH 2 S and serum immunoglobulin E were measured. Results The level of NeH 2 S in general population ranged from 0 to 35 ppb, with a median value of 2 ppb. The NeH 2 S levels in seasonal allergic rhinitis (SAR) patients were significantly lower than those in general population (2 [1, 2.75] vs. 2 [2, 3] ppb; p = .023), and the NeH 2 S value of the SAR group tended to be lower than that of the non‐allergic rhinitis (NAR) group (2 [1, 2.75] vs. 2 [2, 3] ppb; p = .094). The subgroup of AR patients with symptoms lasting longer than 2 weeks per month had a lower NeH 2 S level compared with the subgroup of patients with symptoms lasting less than 2 weeks per month (2 [1, 2] vs. 2 [2, 3] ppb; p = .015). Conclusion This study described the distribution range of NeH 2 S levels in the general population. Further study with larger sample size was needed to clarify the relationship between NeH 2 S level and AR.