Open AccessAmmonia predicts poor outcomes in patients with hepatitis B virus‐related acute‐on‐chronic liver failure
Author(s) -
Zhang JinFei,
Liu XiaoLu,
Ye Bo,
Chen Hui
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23553
Subject(s) - hepatic encephalopathy , medicine , liver failure , hepatitis b virus , gastroenterology , liver disease , encephalopathy , pathogenesis , disease , chronic hepatitis , chronic liver disease , virus , immunology , cirrhosis
Background Hepatic encephalopathy (HE) is a common feature of acute liver failure and has been reported to be associated with poor outcomes. Ammonia is thought to be central to the pathogenesis of HE, but its role in hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF) is unclear. The present study aimed to assess the prognostic role of ammonia level for patients with HBV‐ACLF. Methods We retrospectively recruited 127 patients diagnosed with HBV‐ACLF for the present study. Results Ammonia levels at the time of admission were higher among non‐surviving participants than in survivors. Increased ammonia level was found to be associated with severe liver disease and was identified as an independent predictor for mortality in patients with HBV‐ACLF. Conclusions Our results suggest that high ammonia level at admission is an independent factor for predicting short‐term mortality in patients with HBV‐ACLF. Therefore, ammonia levels may represent a therapeutic target for this condition.