Open AccessAnalysis of serum gastrin‐17 and Helicobacter pylori antibody in healthy Chinese population
Author(s) -
Liu Wenjun,
Sun Youxiang,
Yuan Yulin
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23518
Subject(s) - helicobacter pylori , antibody , gastrin , medicine , population , helicobacter , immunology , gastroenterology , environmental health , secretion
Background Gastrin‐17 (G‐17) and Helicobacter pylori ( H pylori ) antibody are widely used in the screening of gastric diseases, especially in gastric cancer. In this study, we aimed to evaluate the value of G‐17 and H pylori antibody in gastric disease screening. Methods Healthy males and females (1368 and 1212, respectively) aged between 21‐80 years were recruited for the study. Serum G‐17 value was measured using ELISA, and H pylori antibodies were measured using Western blotting. Statistical analyses were performed using the chi‐square, Mann‐Whitney U , and Kruskal‐Wallis H tests. Results Serum G‐17 level was higher in the H pylori‐ positive group than in the negative group. Serum G‐17 level was higher in the type 1 H pylori‐ positive group than in the type 2 H pylori‐ positive group. Further, serum G‐17 level was higher in females than in males and showed significant differences among different age‐groups, with changes in trend proportional to the age. The positive rate of H pylori infection in all the subjects was 58.29% and did not show a significant difference between males and females. However, it showed significant differences among different age‐groups, with the changing trend proportional to the age. Conclusion Analysis of serum G‐17 level and H pylori antibody typing is valuable in gastric disease screening. Every laboratory should establish its own reference interval for G‐17 level.