Open AccessThe association of miR‐27a rs895819 polymorphism with colorectal cancer risk in Chinese population
Author(s) -
Zhang Shulong,
Han Qi,
Zhu Kaihua,
Wang Quan
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23497
Subject(s) - colorectal cancer , medicine , allele , logistic regression , oncology , genotype , taqman , population , gastroenterology , genetics , biology , cancer , gene , real time polymerase chain reaction , environmental health
Background Besides environment and living habits, such as a sedentary lifestyle, smoking and drinking, genetic variation also plays an important role in the development of colorectal cancer (CRC). This study was aimed to investigate the role of miR‑27a rs895819 polymorphism on CRC risk in Chinese population. Methods In a case‐control study including 208 CRC and 312 age‐ and gender‐matched healthy control subjects, the rs895819 polymorphism was genotyped using the TaqMan allelic discrimination assay. Furthermore, a pooled analysis based on eligible studies was performed by using the STATA software. Results Logistic regression analysis showed that the rs895819 polymorphism was not associated with CRC risk. However, a pooled analysis based on five studies from Chinese population showed a statistically significant association between the rs895819 polymorphism and CRC risk (GG vs AA: OR = 1.56, 95% CI = 1.27‐1.92, P z < .01; (AG + GG) vs AA: OR = 1.14, 95% CI = 1.01‐1.30, P z = .04; GG vs (AG + AA): OR = 1.54, 95% CI = 1.27‐1.88, P z < .01; G vs A: OR = 1.20, 95% CI = 1.09‐1.33, P z < .01). Conclusion Our study suggests that miR‑27a rs895819 polymorphism plays an important role in CRC risk in Chinese population and may serve as a valuable biomarker for predicting an individual's susceptibility to CRC.