Open AccessCASR rs1801725 polymorphism is associated with the risk and prognosis of colorectal cancer: A case‐control study
Author(s) -
Diao YuE,
Xu Qing
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23463
Subject(s) - colorectal cancer , medicine , subgroup analysis , gastroenterology , gene polymorphism , meta analysis , oncology , case control study , snp , genotype , single nucleotide polymorphism , gene , cancer , biology , genetics
Abstract Background The extracellular calcium‐sensing receptor (CASR) controls body calcium homeostasis. Increased levels of calcium are associated with protecting against colorectal cancer (CRC). This study aimed to determine the relationship between CASR gene rs1801725 polymorphism and CRC risk and prognosis. Methods We conducted a hospital‐based case‐control study and a meta‐analysis to evaluate the association of CASR gene rs1801725 polymorphism with CRC susceptibility. Results This study proved that CASR rs1801725 polymorphism was associated with a higher risk to develop CRC (TT vs GG: OR 1.92, 95% CI [1.03‐3.59], P = .042; T vs G: OR 1.30, 95% CI [1.03‐1.64], P = .030). Subgroup analysis showed that this polymorphism increased the risk of CRC among smokers, and those aged ≥60 years (TT vs GG: OR 3.37, 95% CI [1.12‐10.14], P = .034). We also found that this polymorphism was associated with the tumor size, TNM stage, and lymph node metastasis of CRC (GT vs GG: OR 2.03, 95% CI [1.32‐3.10], P = .001). In addition, CASR gene rs1801725 polymorphism correlated with the survival of CRC patients. Further meta‐analysis also obtained a significant association between this SNP and CRC risk (TT + GT vs GG: OR 1.28, 95% CI [1.01, 1.63], P = .041). Subgroup analyses by ethnicity observed a link between rs1801725 polymorphism and CRC risk in Asians, but not in Caucasians and mixed populations. Conclusion In conclusion, this case‐control study and meta‐analysis showed that CASR rs1801725 polymorphism increased the risk of CRC. Further studies from other races are urgently needed.