Open AccessAssociations between estimated glomerular filtration rate and cardiac biomarkers
Author(s) -
Pang Lu,
Wang Zhe,
Zhao ZiLong,
Guo Qi,
Huang ChenWei,
Du JiaLin,
Yang HongYun,
Li HaiXia
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23336
Subject(s) - medicine , renal function , confounding , kidney disease , cystatin c , gastroenterology , cardiology , troponin i , endocrinology , urology , myocardial infarction
Background Chronic kidney disease (CKD) is associated with an increased cardiovascular disease (CVD) mortality risk. Elevation of cardiac biomarkers in patients with renal dysfunction is ambiguous in the diagnosis of CVD. The purpose of this study was to investigate the associations between estimated glomerular filtration rate (eGFR) and cardiac biomarkers, and the influence of renal dysfunction on the cardiac biomarkers. Methods We examined the cross‐sectional associations of eGFR with cardiac troponin I (cTnI), creatine kinase (CK), CK‐MB, lactic dehydrogenase (LDH), hydroxybutyrate dehydrogenase (HBDH), and brain natriuretic peptide (BNP) in 812 adults and 215 child. Spearman correlation and logistic regression analysis were performed to evaluate the associations. Results For adults, lower eGFR CKD‐EPI had significantly higher cTnI, CK‐MB, LDH, HBDH, and BNP. There were negative correlations between eGFR CKD‐EPI and cTnI, CK‐MB, LDH, HBDH, and BNP. After adjustment for potential confounders, as compared with eGFR CKD‐EPI ≥ 90 mL/min/1.73 m 2 , eGFR CKD‐EPI < 60 mL/min/1.73 m 2 remained associated with a 2.83 (1.08‐7.41) [ratio (95% CI)] times higher cTnI and a 6.50 (2.32‐18.22) [ratio (95% CI)] times higher HBDH. For child, lower eGFR Schwartz had significant higher CK and CK‐MB. There were negative correlations between eGFR Schwartz and CK, and eGFR Schwartz and CK‐MB. After adjustment for potential confounders, as compared with eGFR Schwartz ≥ 90 mL/min/1.73 m 2 , eGFR Schwartz < 90 mL/min/1.73 m 2 revealed no significant higher CVD biomarkers. Conclusion Reduced eGFR is associated with elevated cTnI and HBDH among adults without clinically evident CVD, but not child.