Open AccessUse of complete blood count for predicting preterm birth in asymptomatic pregnant women: A propensity score‐matched analysis
Author(s) -
Ma Mei,
Zhu Mei,
Zhuo Bimin,
Li Li,
Chen Honglei,
Xu Libo,
Wu Zhihui,
Cheng Feng,
Xu Liangpu,
Yan Jianying
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23313
Subject(s) - medicine , asymptomatic , red blood cell distribution width , obstetrics , gestation , pregnancy , predictive value of tests , complete blood count , predictive value , neutrophil to lymphocyte ratio , predictive marker , propensity score matching , gastroenterology , lymphocyte , genetics , biology , cancer
Background Accurate prediction of preterm birth (PTB) is still difficult, mostly because of the multifactorial etiology of PTB. Previous studies have been mostly focused on the prediction of PTB in symptomatic women or those presenting with threatened preterm labor. We aimed to study whether complete blood count (CBC) parameters at 20‐30 weeks of pregnancy can predict asymptomatic PTB. Methods In this retrospective case‐control study, the preterm and term delivery groups were matched by propensity score‐matched (PSM) analysis. Baseline data and the CBC parameters examined at 20‐30 weeks of gestation were recorded. Results The combined marker of neutrophil‐to‐lymphocyte ratio (NLR), hemoglobin (HGB), and platelet distribution width (PDW) accurately predicts PTB at a cutoff value of 0.25, with sensitivity and specificity of 88.6% and 40.5% and negative and positive predictive value of 97.9% and 10.2%, respectively. Conclusion The combined marker of CBC parameters can supplement other markers to predict PTB about 10 weeks in advance. This combined marker had a very high negative predictive value for PTB. Therefore, in subjects with normal combined marker value, further screening tests for PTB may be eliminated unless clinical suspicion is high.