Open AccessProcalcitonin as a prognostic marker of patients with acute ischemic stroke
Author(s) -
Yan Ling,
Wang Shuling,
Xu Lanlan,
Zhang Zhen,
Liao Pu
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23301
Subject(s) - procalcitonin , medicine , proportional hazards model , logistic regression , univariate analysis , hazard ratio , stroke (engine) , survival analysis , confidence interval , multivariate analysis , sepsis , mechanical engineering , engineering
Background The information on mortality after an acute stroke patient is still limited. Objectives The aim of this study was to investigate the prognostic potential of procalcitonin (PCT) serum levels in acute ischemic stroke. Methods A total of 748 patients were enrolled in this study. Prognostic potential of PCT was evaluated by Kaplan‐Meier analysis and multivariable Cox hazard regression analyses. Results Procalcitonin levels were found to be significantly higher in acute ischemic stroke patients who died in 30 days than those who survived. Univariate logistic regression analysis showed that PCT was significantly associated with 30‐day mortality, and Cox regression analysis revealed that PCT was a strong predictor of 30‐day overall mortality. Kaplan‐Meier analysis revealed that overall cumulative 30‐day mortality was significantly higher in those with PCT levels >1.5 ng/mL when compared to those with PCT levels <1.5 ng/mL. Conclusions Procalcitonin is a significant independent prognostic marker of 30‐day mortality after the one set of acute ischemic stroke.