Open AccessT‐cell blast crisis of chronic myelogenous leukemia presented with coexisting p210 and p190 BCR‐ABL transcripts and t(10;11)(q11;p15)
Author(s) -
Xia Ting,
Yang Yuchao,
Li Guoxia,
Chang Jianmei,
Li Jianlan,
Ren Fanggang,
Ren Weixiao,
Wang Hongwei,
Xu Zhifang
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23241
Subject(s) - chronic myelogenous leukemia , cd38 , immunophenotyping , philadelphia chromosome , breakpoint cluster region , chromosomal translocation , cd33 , cancer research , blast crisis , leukemia , cd8 , biology , immunology , medicine , cd34 , flow cytometry , immune system , genetics , stem cell , gene , receptor
Background Blast transformation of chronic myelogenous leukemia (CML) to T lymphoblastic lymphoma/acute lymphoblastic leukemia (T‐LBL/ALL) is rare, and the molecular mechanism is still unclear. Case report A 28‐year‐old woman who developed T‐ALL with coexpressing both p210 and p190 BCR‐ABL transcripts five years after the initial diagnosis of CML in chronic phase. The proliferation of bone marrow was extremely active with blast cells over 20%. Chromosome analysis revealed t(9;22)(q34;q11) and t(10;11)(q25;p15). Flow immunophenotyping showed that blasts expressed CD4, CD7, CD11b, CD38, CD34, CD33, and cCD3. Conclusion It is the first T‐cell blast of CML case with coexisting p210 and p190 as well as additional chromosome translocations. Through review this case and previous reports, we will reveal that CML patients with T‐lymphocyte transformation depend on potential molecular and pathological mechanism.