Open AccessAssociation between obesity categories with cardiovascular disease and its related risk factors in the MASHAD cohort study population
Author(s) -
Ghazizadeh Hamideh,
Mirinezhad Seyed Mohammad Reza,
Asadi Zahra,
Parizadeh Seyed Mostafa,
ZareFeyzabadi Reza,
Shabani Niloofar,
Eidi Marziyeh,
Mosa Farkhany Ehsan,
Esmaily Habibollah,
Mahmoudi Ali Asghar,
Mouhebati Mohsen,
Oladi Mohammad Reza,
Rohban Mohadeseh,
Sharifan Payam,
Yadegari Mehran,
Saeidi Fatemeh,
Ferns Gordon A.,
GhayourMobarhan Majid
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23160
Subject(s) - medicine , dyslipidemia , obesity , body mass index , waist , odds ratio , metabolic syndrome , risk factor , diabetes mellitus , cohort , population , logistic regression , endocrinology , environmental health
Background Cardiovascular disease (CVD) is a significant cause of morbidity and mortality globally. Obesity is an important CVD risk factor and is increasing in prevalence. Methods In this study, 3829 men and 5720 women (35‐65 years) were enrolled as part of the MASHAD cohort study. Four categories were identified according to body mass index and waist circumference that was defined by the World Health Organization. Logistic regression analysis was used to determine the adjusted odds ratio (OR) for the occurrence of CVD, and Cox regression model was used to evaluate the association of obesity with CVD incidence. Results We found that the higher risk groups defined by categories of adiposity were significantly related to a higher prevalence of a high serum total cholesterol (TC), and triglycerides (TG), and lower high‐density lipoprotein cholesterol (HDL), and higher fasting blood glucose (FBG) in both genders and a higher low‐density lipoprotein cholesterol (LDL) in women ( P < .001). Additionally, a high percentage of participants with dyslipidemia, high LDL, high TC, and low HDL and a high percentage of participants with metabolic syndrome, diabetes, hypertension, and a high serum TG were observed across obesity categories ( P < .001 ) . Moreover, women with the very high degrees of obesity had a greater risk of CVD (HR: 1.91, 95% CI: 1.06‐3.43, P = .03). Conclusion Obesity strongly predicts several CVD risk factors. Following 6 years of follow‐up, in individuals within increasing degrees of obesity, there was a corresponding significant increase in CVD events, rising to approximately a twofold higher risk of cardiovascular events in women compared with men.