Open AccessEvaluating hypercoagulability in new‐onset systemic lupus erythematosus patients using thromboelastography
Author(s) -
Gong Huiyun,
Shi Ce,
Zhou Zhuochao,
Teng Jialin,
Sun Yue,
Yang Chengde,
Wang Xuefeng,
Ye Junna
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23157
Subject(s) - thromboelastography , medicine , lupus anticoagulant , coagulation , platelet , coagulation testing , prospective cohort study , immunology , gastroenterology , thrombosis
Background Thromboelastography (TEG) can reflect the coagulation status in vivo, from clot formation to clot lysis. In the present study, we aimed to evaluate the function of TEG in detecting coagulation in patients with SLE and sought to explore the correlation between clinical and laboratory data. Methods A total of 41 patients with new‐onset SLE who had not undergone treatment and 56 healthy controls were included. TEG and other laboratory tests were performed, and clinical data were collected. Results A significant difference in the TEG reaction time and TEG achievement of clot firmness was observed between the groups. Moreover, these parameters were correlated with the lupus anticoagulant levels, platelet count, 24‐hour urinary total protein quantity, and systemic lupus erythematosus disease activity index. Conclusion Our study demonstrated the prospective value of TEG in evaluating hypercoagulability in patients with SLE.