Open AccessEndothelin‐1 rs9296344 associates with the susceptibility of childhood primary nephrotic syndrome
Author(s) -
Zhang Ruifeng,
Yang Huandan,
Zhu Bingbing,
Yuan Tingting,
Peng Qianqian,
Lv Juan,
Qiu Shan,
Zhou Suqin,
Li Yan,
Zhong Zhaowen
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23134
Subject(s) - single nucleotide polymorphism , odds ratio , snp , logistic regression , confidence interval , allele , genetics , biology , medicine , genotype , bioinformatics , gene
Background Recently, the rs5370 single nucleotide polymorphisms (SNPs) of Endothelin‐1 ( EDN1) showed association with the susceptibility of childhood primary nephrotic syndrome (CPNS). This study aims to investigate potential relationships between other EDN1 SNPs and CPNS. Methods Seven SNPs (rs5370, rs10478723, rs1476046, rs1800541, rs2070698, rs2071942, and rs9296344) of the EDN1 gene were genotyped in 579 CPNS patients and 586 age‐matched healthy children. Then, we analyzed potential associations of the six SNPs with susceptibility of CPNS by using rs5370 as a conditional variant in a logistic regression model. SNP‐SNP interaction analysis was performed to investigate the joint effects of the seven SNPs in the pathogenesis of CPNS. Results Independent with rs5370, only rs9296344 significantly associated (T vs C, odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.57‐0.88, P = .001) with the susceptibility of CPNS. Meanwhile, no joint effect among the analyzed seven SNPs was discovered in this study. Conclusions This study discovered that C allele of rs9296344 on EDN1 is a novel independent risk factor for CPNS.