Open AccessThe variation degree of coagulation function is not responsible for extra risk of hemorrhage in gestational diabetes mellitus
Author(s) -
Dong Chang,
Gu Xiaoqiong,
Chen Fei,
Long Yanlan,
Zhu Dan,
Yang Xia,
Qiu Xiu,
Gao Guoquan,
Qi WeiWei
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23129
Subject(s) - medicine , mean platelet volume , gestational diabetes , partial thromboplastin time , fibrinogen , pregnancy , prothrombin time , diabetes mellitus , thromboelastography , platelet , coagulation , hemostasis , obstetrics , prospective cohort study , gastroenterology , gestation , endocrinology , biology , genetics
Background Gestational diabetes mellitus (GDM) is characterized as glucose intolerance of any degree that begins or first diagnosed during pregnancy. It possesses a higher risk of haemorrhage, which may be caused by the coagulation dysfunction. However, there has been no study focus on how coagulation state changes in the progress of GDM pregnancy. Our study is aimed to assess the association of coagulation function and haemorrhage in GDM. Methods A total of 662 subjects (273 from a population‐based study and 389 from a prospective cohort study) were selected to measure mean platelet volume (MPV), platelet distribution width (PDW), platelet (PLT), thrombocytocrit (PCT), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FIB). All pregnant individuals were divided into normal glucose tolerance (NGT) controls and GDM patients diagnosed between the 24th and 28th weeks of gestation. Results Compared with NGT controls, GDM females showed shortened PT, shortened APTT, and increased blood FIB levels, while the platelet parameters MPV, PDW, PLT, and PCT remained unchanged in mid‐pregnancy. By late pregnancy, the platelet parameters MPV, PDW, and PCT were increased in the GDM group compared with the NGT group, while PT and APTT were unchanged. Conclusions The GDM group was hypercoagulable compared with the NGT group rather than hypocoagulable as predicted, but still within the normal range. Therefore, our findings demonstrate that the variation degree of coagulation function is not responsible for extra risk of hemorrhage in GDM, and prevention of hemorrhage should focus on other causes.