Open AccessAssociation between the miRNA‐149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population
Author(s) -
Li Jiawen,
Wang Jinxin,
Su Xiaoping,
Jiang Zhiyong,
Rong Xing,
Gu Xueping,
Jia Chang,
Zeng Lanlan,
Zheng Hao,
Gu Xiaoqiong,
Chu Maoping
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.23125
Subject(s) - kawasaki disease , taqman , medicine , gastroenterology , vasculitis , etiology , genotype , polymorphism (computer science) , coronary artery disease , systemic vasculitis , single nucleotide polymorphism , immunology , disease , genetics , biology , artery , real time polymerase chain reaction , gene
Background Kawasaki disease (KD), which is characterized by vasculitis, is prone to occur in patients under 5 years of age, has an ambiguous etiology, and displays coronary artery lesions as the chief complication. Previous studies have linked miRNA‐149 to cancers, and rs2292832 T>C is related to allergic diseases and inflammatory bowel disease, which both show immune system disorders and coronary artery disease. Therefore, we performed a study concentrating on the association between the miRNA‐149 rs2292832 T>C polymorphism and KD susceptibility. Methods The subjects enrolled were 532 children with KD and 623 controls. We used TaqMan real‐time PCR to obtain the genotypes of the rs2292832 T>C polymorphism. Results Ultimately, no significant association was found between the miRNA‐149 rs2292832 T>C polymorphism and KD susceptibility, even in stratification analysis. Conclusion Our results indicated that in southern Chinese patients, the miRNA‐149 rs2292832 T>C polymorphism did not affect KD susceptibility, which needs to be further confirmed.