Open AccessTherapeutic effect of high‐frequency ultrasound‐assisted dye laser on hemangioma and its influence on serum HIF‐1α in patients
Author(s) -
Hu Hongzhang,
Song Pengyuan,
Yang Jinyan,
Wang Xia,
Chen Zhaohui,
Fang Jianhua
Publication year - 2020
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22970
Subject(s) - hemangioma , medicine , ultrasound , laser treatment , therapeutic effect , significant difference , laser , radiology , surgery , physics , optics
Background To analyze the therapeutic effect of high‐frequency ultrasound (HFU)‐assisted dye laser on hemangioma patients and changes in serum hypoxia‐inducible factor‐1α (HIF‐1α). Methods A total of 20 patients diagnosed with hemangioma in our hospital from January 2013 to March 2018 were selected, including 12 males and eight females. All patients were treated with HFU‐assisted dye laser. The site and type of hemangioma and age distribution of patients were collected, and changes in data and area of hemangioma and serum HIF‐1α before and after treatment were analyzed. Results The vascular condition of hemangioma in all patients was significantly improved at 7, 14, and 30 days after treatment. Gray‐scale ultrasound displayed that the tumor area was reduced by more than 50%. After treatment, the serum HIF‐1α level declined obviously after treatment compared with that before treatment, showing a statistically significant difference ( P < 0.05). Conclusion HFU‐assisted dye laser can effectively reduce the tumor area, decrease the serum HIF‐1α level, and improve the prognosis in the treatment of hemangioma.