Open AccessInvestigation of association between LINC00673 rs11655237 C>T and Wilms tumor susceptibility
Author(s) -
Gao Xiaofeng,
Jia Wei,
Zhu Jinhong,
Fu Wen,
Zhu Shibo,
Xia Huimin,
He Jing,
Liu Guochang
Publication year - 2019
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22930
Subject(s) - odds ratio , confidence interval , medicine , gastroenterology , wilms' tumor
Background Wilms tumor (WT) is the most common pediatric renal malignancy. Previous genome‐wide association studies have identified that the LINC00673 rs11655237 C>T polymorphism is associated with the risk of several types of cancer. However, few studies have investigated the association between LINC00673 rs11655237 C>T and WT susceptibility. Method We genotyped LINC00673 rs11655237 C>T in 145 patients with WT and 531 cancer‐free controls recruited from southern Chinese children. The strength of association was estimated by odds ratios (ORs) and 95% confidence intervals (CIs). Results Our study indicated that there was no significant association between LINC00673 rs11655237 C>T polymorphism and WT risk under all the tested genetic models (CT vs CC: adjusted OR = 0.94, 95% CI = 0.63‐1.40; TT vs CC: adjusted OR = 0.60, 95% CI = 0.22‐1.59; TT/CT vs CC: adjusted OR = 0.89, 95% CI = 0.61‐1.31; and TT vs CC/CT: adjusted OR = 0.61, 95% CI = 0.23‐1.61). Further stratified analysis detected no significant association, either. Conclusion In conclusion, we failed to find any association between the LINC00673 rs11655237 C>T polymorphism and WT risk. This finding needs to be verified in larger studies and other populations.